Refix Drug Interactions

Capsule: Carbamazepine: Elevated carbamazepine levels have been reported when administered concomitantly with cefixime. Drug monitoring when these drugs are given together is advised.
Chloramphenicol: In vitro and in vivo antagonism have been noted between cephalosporins and chloramphenicol against a variety of Gram-positive and Gram-negative bacteria; therefore, it is recommended that combined therapy with chloramphenicol and cephalosporin be avoided particularly when bactericidal activity is considered important.
Nifedipine: Concomitant administration of cefixime and nifedipine increases oral bioavailability of cefixime as a result of higher C_max and AUC.
Probenecid: Concomitant administration of probenecid reportedly increases C_max and AUC of cefixime and decreases renal clearance and volume of distribution of the drug.
Salicylates: Concomitant administration of 650 mg oral dose and 400 mg oral dose of cefixime in healthy adult men may result in a 20 to 25% decrease in C_max and AUC of cefixime but did not affect protein binding, serum t_1/2, or renal clearance. This effect may not be clinically important since serum concentrations of cefixime remained higher than the MIC values reported for most susceptible organisms. However, some clinicians state that this effect may be clinically important in certain infections.
Warfarin and other anticoagulants: Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is given concomitantly.
Granules for oral suspension: Care should be exercised in patients receiving anticoagulants and cefixime due to the possibility that cefixime may increase prothrombin times.