Reinin Dosage/Direction for Use

In patients with poor general health, i.e., low body weight, after organ transplantation, etc., the dose should be titrated more slowly, either by using smaller dosage strengths or longer intervals between dosage increases.
It is not necessary to monitor gabapentin plasma concentration to optimize gabapentin therapy.
If gabapentin is reduced, discontinued and/or an alternate anticonvulsant drug is added to the therapy, this should be done gradually over a minimum of one week. (See Table 1.)

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Dosage in Patients with Renal Impairment: Dosage adjustment is recommended in patients with impaired renal function and those undergoing hemodialysis. (See Table 2.)

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Dosage in Patients Undergoing Hemodialysis: For anuric patients undergoing hemodialysis who have never received gabapentin: A loading dose of 300-400 mg, then 200-300 mg of gabapentin following each 4 hours of hemodialysis, is recommended. On dialysis free days, there should be no treatment with gabapentin.
For renally impaired patients undergoing hemodialysis: The maintenance dose of gabapentin should be based on the dosing recommendations shown in Table 2. In addition to the maintenance dose, an additional 200-300 mg dose following each 4-hour hemodialysis treatment is recommended.
Or, as prescribed by a physician.