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The central effects of other CNS depressants, including alcohol, may be enhanced by Risperidone. Risperidone may enhance the effects of antihypertensives. There may be an increased risk of QT prolongation when Risperidone is given with other drugs that are known to cause this effect. Risperidone may antagonize the actions of levodopa and other dopaminergics.
Carbamazepine has been shown to decrease the atypical antipsychotic fraction (Risperidone plus 9-hydroxyrisperidone) of Risperidone and a similar effect may be seen with other enzyme inducers. Fluoxetine may increase the plasma concentrations of the atypical antipsychotics fraction by raising the concentration of Risperidone. Dose adjustment of Risperidone may be necessary in such situations.
