Schizophrenia including the 1st psychotic episode, acute schizophrenic episodes, chronic schizophrenia & other psychotic conditions where +ve &/or -ve symptoms are intense. Alleviates emotional disorders that relate to schizophrenia. Behavioral disorders in patients w/ dementia whose symptoms are intense. Additional treatment in mood stabilizers for manic episodes accompanied by bipolar disorders. Developmental & other disorders of disruptive behavior in patients w/ mental function that is rated under the average or mental retirement, whose destructive behavior is intense.
Initially 2 mg daily in 1 or 2 divided doses, may be increased to 4 mg daily on the 2nd day & subsequently adjusted in increments/decrements of 1 or 2 mg daily at intervals of not less than 1 wk. Max: 16 mg daily. Elderly & patient w/ renal or hepatic impairment Initially 0.5 mg bid slowly increased in steps of 0.5 mg bid if necessary to 1-2 mg bid.
May cause involuntary facial movements in long-term use. May increase body wt. Patients w/ CV diseases, disturbed renal or hepatic function, Parkinson's disease, epilepsy. Avoid during pregnancy. Not recommended during lactation. Childn <15 yr. Elderly.
May increase actions of alcohol & of medicines that reduce the ability to react ie, tranquilizers, narcotic analgesics, several antihistamines, antidepressants & antihypertensives. May antagonize action w/ drugs for Parkinson's disease (dopamine agonists ie, levodopa). May affect effectiveness w/ drugs used mainly in epilepsy or trigeminal neuralgia (strong facial pain).
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