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Estrogen/Hormone Replacement Therapy (HRT): Combined use of alendronate and HRT resulted in greater increases in bone mass, together with greater decreases in bone turnover, than seen with either treatment alone. The safety and tolerability profile of the combination was consistent with those of the individual treatments.
Calcium Supplements/Antacids: It is likely that calcium supplements, antacids and some oral medications will interfere with absorption of alendronate. Therefore, patients must wait at least ½ hr after taking alendronate before taking any other oral medications.
Aspirin: The incidence of upper gastrointestinal adverse events increased in patients receiving concomitant therapy with daily doses of alendronate >10 mg and aspirin-containing products.
Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Since NSAID use is associated with gastrointestinal irritation, caution should be used during concomitant use with alendronate.
