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In premarketing clinical trials, one case of accidental overdose with 40 mg/kg SUGAMMADEX was reported without significant effects.
SUGAMMADEX can be removed using hemodialysis with a high-flux filter, but not with a low-flux filter. Based upon clinical studies, SUGAMMADEX concentrations in plasma are reduced with a high-flux filter by about 70% after a 3- to 6-hour dialysis session.
