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Oral anticoagulants: it may increase the intensity of bleedings.
Glycoprotein IIb/IIIa inhibitors, Acetylsalicylic acid, Heparin, NSAIDs: may increase the risk of bleeding.
Drugs that inhibiting CYP2C19: may cause reduced drug levels of the active metabolite of clopidogrel.
Ciclosporin: rosuvastatin AUC values may increase.
Vitamin K antagonists: may result in an increase in International Normalised Ratio (INR).
Gemfibrozil and other lipid-lowering products: may result in increase of rosuvastatin Cmax, and AUC.
Protease inhibitors: may strongly increase rosuvastatin exposure.
Antacid: antacid suspension containing aluminum and magnesium hydroxide may result in a decrease in rosuvastatin plasma concentration.
Erythromycin: may result in decrease in AUC(0-t) and Cmax of rosuvastatin.
Oral contraceptive/hormone replacement therapy (HRT): may result in an increase in ethinyl estradiol and norgestrel AUC of 26% and 34%, respectively. These increased plasma levels should be considered when selecting oral contraceptive doses.
