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Before instituting therapy with rosuvastatin, an attempt should be made to control hypercholesterolemia, with appropriate diet, exercise and weight reduction in obese patients and to treat other underlying medical problems. When initiating statin therapy or switching from another statin therapy, the appropriate rosuvastatin starting dose should be first be utilized and only then titrated according to the patient's individualized goal of therapy. HMG-CoA reductase inhibitors eg, some other lipid-lowering therapies, have been associated with biochemical abnormalities of liver function. It is recommended that liver function tests be performed before and at 12 weeks following both the initiation of therapy and any elevation of dose and periodically thereafter.
Use in Children: Safety and efficacy have not been established in children.
