Treatment & prevention of recurrence depressionAdult Initially 50 mg once daily, increased in increments of 50 mg at interval of at least 1 wk. Max: 200 mg daily.
Avoid use in patients taking electroconvulsive therapy & w/ unstable epilepsy. Discontinue if seizures develop. Avoid concomitant use w/ MAOIs for at least 14 days prior to initiation of therapy. Not to be used in severe hepatic or renal impairment. May impair ability to drive or operate machinery. Pregnancy & lactation.
Not recommended w/ alcohol. Concomitant use w/ other centrally acting medications. May cause higher incidence of 5-HT associated adverse effects w/ lithium & tryptophan. May cause a shift in plasma conc in co-administration w/ drugs that are highly protein-bound.
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