The activity of Ceftazidime against Pseudomonas aeruginosa and some Enterobacteriaceae may be enhanced by aminoglycosides. Nephrotoxicity and ototoxicity has been reported following concomitant administration of cephalosporins with aminoglycosides antibiotics or potent diuretics such as furosemide. These were not noted when ceftazidime is given alone. Antagonism has been reported in vitro between ceftazidime and chloramphenicol.
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