Tazivex Mechanism of Action

Pharmacology: Pharmacokinetics: Absorption: Ceftazidime is administered by injection as the sodium salt or in solution with arginine. Mean plasma concentrations of 17 and 39 μg per mL have been reported approximately one hour after intramuscular administration of 0.5 and 1 gram Ceftazidime respectively. Five minutes after intravenous bolus injections of 0.5, 1 and 2 g of Ceftazidime, mean plasma concentrations of 45, 90 and 170 μg per mL respectively, have been reported. The plasma half-life of Ceftazidime is about 2 hours, but this is prolonged in patients with renal failures and neonates. Clearance may be enhanced in patients with cystic fibrosis. It is about 10 to 17% bound to plasma proteins.
Distribution: Ceftazidime is widely distributed in body tissues and fluids, therapeutic concentration is achieved in the cerebrospinal fluid when the meninges are inflamed. It crosses the placenta and is excreted in the breast milk.
Elimination: Ceftazidime is passively excreted in bile, although only small proportion is eliminated by this route. It is mainly excreted by the kidneys, almost exclusively by glomerular filtration; about 80 to 90% of dose is recovered unchanged in the urine within 24 hours.