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Although TIMOLOL MALEATE (TIMOPTOL) used alone has little or no effect on pupil size, mydriasis resulting from concomitant therapy with TIMOLOL MALEATE TIMOPTOL) and therapy has been reported occasionally.
Potentiated systemic beta-blockers (eg, decreased heart rate, depression) has been reported during combined treatment with CYP2D6 inhibitors (eg, quinidine, SSRIs) and timolol.
The potential exists for additive effects and production of hypotension and/or marked bradycardia when TIMOLOL MALEATE (TIMOPTOL) is administered together with an oral calcium-entry blocker, catecholamine-depleting drugs, antiarrhythmics, parasympathomimetics or β-adrenergic blocking agents.
Oral β-adrenergic blocking agents may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
