Tozam Overdosage

Losartan Potassium: Symptoms: The most likely manifestation of over-dosage would be hypotension and tachycardia. Bradycardia could occur from parasympathetic (vagal) stimulation. Treatment: If symptomatic hypotension occurs, supportive treatment should be instituted. Neither Losartan Potassium nor E-3174 can be removed by hemodialysis.
Amlodipine Besilate: Symptoms: Available data suggests that the gross over dosage could result in excessive peripheral vasodilation with marked and probably prolonged hypotension and possibly a reflex tachycardia. Treatment: Since absorption of amlodipine is slow, gastric lavage should be performed. Active cardiovascular support including monitoring of cardiac and respiratory function, elevation of extremities, and attention of circulating fluid volume and urine output should be given. Intravenous calcium gluconate may help to reverse the effects of calcium entry blockade. A vasoconstrictor agent may be helpful in restoring vascular and blood pressure provided that there is no contraindication to its use. Since amlodipine is highly protein bound, dialysis is unlikely to be of benefit.