Tremfya

Tremfya

guselkumab

Manufacturer:

Cilag AG

Distributor:

Johnson & Johnson
Concise Prescribing Info
Contents
Guselkumab
Indications/Uses
Plaque, scalp, nail, & hand & foot psoriasis in adults w/ moderate to severe psoriasis who are candidates for phototherapy or systemic therapy. Active psoriatic arthritis in adults. Palmoplantar pustulosis (PPP) in adults who do not adequately respond to conventional therapy.
Dosage/Direction for Use
SC Adult ≥18 yr Plaque psoriasis, PPP 100 mg at wk 0 & 4, & every 8 wk thereafter. Psoriatic arthritis 100 mg at wk 0 & 4, & every 8 wk thereafter or; 100 mg at wk 0 & every 4 wk thereafter. May be administered alone or in combination w/ conventional synthetic DMARD eg, MTX. Switching from other biologic (ustekinumab or adalimumab therapy) Administer at wk 0 & 4, & every 8 wk thereafter.
Special Precautions
Discontinue use if a serious hypersensitivity reaction occurs. May increase risk of infection; not to be given in patients w/ clinically important, active infection. Evaluate patients for Tb prior to treatment; not to be administered in patients w/ active Tb; treat latent Tb prior to treatment. Avoid use of live vaccines. Renal & hepatic impairment. Pregnancy & lactation. Childn <18 yr. Elderly ≥65 yr.
Adverse Reactions
Resp tract infections. Increased transaminases; headache; diarrhea; arthralgia; inj site erythema.
Drug Interactions
Do not give live vaccines during therapy.
MIMS Class
Immunosuppressants / Psoriasis, Seborrhea & Ichthyosis Preparations
ATC Classification
L04AC16 - guselkumab ; Belongs to the class of interleukin inhibitors. Used as immunosuppressants.
Presentation/Packing
Form
Tremfya soln for inj 100 mg/mL
Packing/Price
1's
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