Tri-Alzor Dosage/Direction for Use

Posology: Dosage may be increased in 2 week intervals, as needed. The maximum recommended dose of combination (olmesartan medoxomil, amlodipine and hydrochlorothiazide) is 40/10/25 mg.
Dose once daily. Do not crush the tablet. Or as prescribed by the physician.
Dose selection should be individualized based on previous therapy.
Pediatric patients: The safety and effectiveness of the combination of olmesartan medoxomil, amlodipine and hydrochlorothiazide in pediatric patients have not been established.
Elderly Patients: Caution, including more frequent monitoring of blood pressure, is recommended in elderly people.
An increase of the dosage should take place with care in elderly people.
Hepatic impairment: The combination of olmesartan medoxomil, amlodipine and hydrochlorothiazide should be used with caution in patients with mild hepatic impairment.
In patients with moderate hepatic impairment the maximum dose should not exceed Tri-Alzor 20 mg/5 mg/12.5 mg once daily.
Close monitoring of blood pressure and renal function is advised in patients with hepatic impairment.
As with all calcium antagonists, amlodipine's half-life is prolonged in patients with impaired liver function and dosage recommendations have not been established. Tri-Alzor should therefore be administered with caution in these patients. The pharmacokinetics of amlodipine have not been studied in severe hepatic impairment. Amlodipine should be initiated at the lowest dose and titrated slowly in patients with impaired liver function.
Use of Tri-Alzor is contraindicated in patients with severe hepatic impairment, cholestasis or biliary obstruction.
Renal Impairment: There are no studies of the combination of olmesartan medoxomil, amlodipine and hydrochlorothiazide in patients with renal impairment. Avoid use in patients with severe renal impairment (creatinine clearance < 30 mL/min).
Method of administration: The tablet should be swallowed with a sufficient amount of fluid (e. g. one glass of water). The tablet should not be chewed and should be taken at the same time each day.
Tri-Alzor can be taken with or without food.