Pharmacology: Pharmacokinetics: Ceftriaxone demonstrates nonlinear dose-dependent pharmacokinetics because of its protein binding: about 85 to 95% is bound to plasma protein depending on the plasma concentration of Ceftriaxone. Mean peak plasma concentrations of about 40 and 80 μg per mL have been reported 2 hours after intramuscular injection of 0.5 and 1 gram of Ceftriaxone respectively. The plasma half-life of Ceftriaxone is not dependent on the dose and varies between 6 and 9 hours; it may be prolonged in neonates. It is widely distributed in body tissues and fluids. It crosses both inflamed and non-inflamed meninges, generally achieving therapeutic concentrations in the CSF. It crosses the placenta and low concentrations have been detected in breast milk. About 40 to 65% of a dose of Ceftriaxone is excreted unchanged in the urine, principally by glomerular filtration.
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