Infrequent and minor adverse effect reactions include metallic taste, furred tongue and dry mouth, gastrointestinal disturbances such as diarrhea, anorexia, vomiting, epigastric distress, constipation, occasional flushing, and headaches, especially with concomitant ingestion with alcohol, dizziness and rarely incoordination and ataxia have been reported. Occasionally, patients have complained of numbness' or paresthesia of extremities, fleeting joint pains have been experienced, as have confusion, irritability, depression, urticaria, pruritus, dysuria, cystitis, urethral discomfort and darkening of the urine have occurred in patients receiving the drug.