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Metronidazole has been shown to be carcinogenic in mice. Unnecessary use of the drug should be reserved for conditions described in the indications.
The use of this drug in the first trimester of pregnancy should be avoided. During the second trimester of pregnancy, its use should be restricted to those patients in whom topical measures have been proven inadequate. Metronidazole is secreted in the breast milk when administered to nursing mothers. Its use should be avoided although there is no reported effect to the newborn.
