Multivitamins, iron, docusate sodium.
Each tablet contains: Ascorbic Acid (Vitamin C) 600 mg, Ferrous Fumarate (115 mg Elemental Iron) 350 mg, Intrinsic Factor Concentrate 75 mg, dl-Alpha Tocopheryl Acetate (Vitamin E) 60 mg, Docusate Sodium 50 mg, Folic Acid 1 mg, Cyanocobalamin (Vitamin B12) 25 mcg.
Excipients/Inactive Ingredients: Other components: Starch 80 mg, Opadry Red 28 mg.
Pharmacology: Pharmacodynamics/Pharmacokinetics: Multivitamins + Iron + Docusate sodium (TriHEMIC) is a preparation containing ingredients essential to normal erythropoiesis, plus a stool softener to counteract the constipating effects of iron.
Iron is irregularly and incompletely absorbed from the gastrointestinal tract, the main sites of absorption being the duodenum and jejunum. Absorption is aided by the acid secretion of the stomach and by some dietary acids (such as ascorbic acid) and occurs more readily when the iron is in the ferrous state or is part of the haem complex (haem-iron). Absorption is also increased in conditions of iron deficiency or in the fasting state but is decreased if the body stores are overloaded. Normally only about 5 to 15% of the iron ingested in food is absorbed. Only very small amounts of iron are excreted as the majority released after the destruction of the hemoglobin molecule is re-used. This conservation of body iron, and lack of an excretory mechanism for excess iron, is the reason for the development of iron overload with excessive iron therapy or repeated transfusions.
Docusate Sodium works by actively drawing water into the stool, thus softening the stool and achieving ease in bowel movement.
Multivitamins+ Iron + Docusate sodium (TriHEMIC) acts as hematinic in iron deficiency anemia.
One tablet daily. Adjustment of dosage is dependent on patient's response and the physician's clinical judgment.
Maternal and neonatal hypomagnesemia following chronic maternal ingestion of docusate sodium (100 - 200 mg/day during pregnancy) may occur.
In case of accidental overdose or at the first sign of any adverse reaction, discontinue use and seek professional assistance immediately.
This product is contraindicated in patients who are allergic (hypersensitive) to its active ingredients and components such as starch, opadry red and alcohol. Alcohol may contain allergens like yeasts and products thereof which may cause allergic reactions. It is also contraindicated in patients taking mineral oil, with intestinal obstruction, and acute abdominal pain.
Folic Acid alone is an improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where Cyanocobalamin (Vitamin B12) is deficient.
Some patients afflicted with pernicious anemia may not respond to orally administered Cyanocobalamin (Vitamin B12) with intrinsic factor concentrate and there is no known way to predict which patients will respond or which patients may cease to respond. Periodic examinations and laboratory studies of pernicious anemia patients are essential and recommended. If any symptoms of intolerance occur, the drug should be temporarily or permanently discontinued. Folic Acid in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestations remain progressive. Doses greater than 10 mcg of Cyanocobalamin (Vitamin B12) may produce a hematological response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis.
As with any medication, women who are pregnant or breastfeeding should seek the advice of a healthcare professional before taking this product.
Gastrointestinal intolerance may develop and be manifested as nausea, vomiting, diarrhea or abdominal pain. Skin rashes of various types may occur. Such reactions may necessitate temporary or permanent changes in dosage or usage. Allergic sensitization has been reported following both oral and parenteral administration of Folic Acid.
Docusate Sodium: Droperidol: Concurrent use of Droperidol with Docusate may result in an increased risk of cardiotoxicity. It should be administered with extreme caution in the presence of risk factors for development of prolonged QT.
Levomethadyl: The use of this drug with Docusate may result in an increased risk of QT prolongation.
Licorice: Increase risk of hypokalemia may occur when taken simultaneously with this drug. Avoid concomitant use of licorice and laxatives.
Mineral Oil: May cause inflammation of intestinal mucosa, liver, spleen, and lymph nodes when taken alongside with this drug. Avoid concurrent oral administration of docusate salts and mineral oil.
Store at temperatures not exceeding 30°C.
B03AE10 - various combinations ; Belongs to the class of iron in other combinations. Used in the treatment of anemia.
TriHEMIC tab
100's (P1,775/box, P17.75/tab)
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