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For the first year of therapy, serum transaminase should be monitored periodically, every 3 months. Therapy should be discontinued and if there is an increase of SGPT concentration >100 unit/L.
Combination therapy of hepatotoxic substances eg, MAOI is not recommended.
If 3 months after therapy, the reduction of serum concentration of lipid is not satisfactory, other therapeutic agents should be considered.
