Route of Administration: Usually administered orally. The usual dose for healing reflux oesophagitis is 20 to 40 mg once daily for 4 to 8 weeks; thereafter maintenance therapy can be continued with 20 mg once daily.
In the management therapy can be continued with 20 mg once daily.
In the management of peptic ulcers a single daily dose of 20 mg, or 40 mg in severe cases, is recommended usually for 4 weeks in patients with duodenal ulcer and for 8 weeks in those with gastric ulcers. Treatment for longer periods is not yet recommended; therefore omeprazole is not used for long-term maintenance.
The initial recommended dosage for patients with the Zollinger-Ellison syndrome is 60 mg once daily, but doses in the range 20 to 120 mg daily may be used; doses above 80 mg should be divided and given twice daily.
In such patients treatment with omeprazole is continued as required to keep the condition under control.