Not to be given in patients w/ GI tract ulceration or inflammation; history of stroke (CVA), heart attack (MI), CABG, uncontrolled HTN & CHF. Frequently monitor prothrombin time in concurrent administration w/ oral anticoagulant drugs. Ensure adequate hydration & monitor renal function in the beginning of concomitant treatment w/ antihypertensive drugs & periodically thereafter. Renal or hepatic impairment. Pregnancy & lactation.
May enhance response to oral anticoagulants eg, warfarin. Reduced efficacy of diuretics & other hypertensive drugs. Increased renal function deterioration including possible acute renal failure w/ ACE inhibitor. Increased risk of GI ulceration or bleeding w/ corticosteroids. Increased risk of nephrotoxicity w/ cyclosporine. Change in effects of insulin or oral hypoglycemic agents. Elevated plasma levels & reduced renal clearance of lithium. May increase plasma levels of MTX. Possible increased risk of nephrotoxicity w/ tacrolimus.
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