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Drug Class: Non-steroidal Anti-inflammatory Drugs (NSAIDs).
Pharmacology: Pharmacodynamics: Mefenamic acid (Vamgesic) is non-steroidal agent with demonstrated anti-inflammatory, analgesic, and antipyretic activity in laboratory animals. Mefenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor sites in animal models.
Pharmacokinetics: Mefenamic acid (Vamgesic) is absorbed from the gastro-intestinal tract.
Peak Plasma Concentration: 1-4 hours after ingestion.
Plasma Elimination Half-life: 2-4 hours.
Mefenamic acid (Vamgesic) is extensively bound to plasma proteins. Small amounts have been detected in breast milk. Over 50% of a dose may be recovered in the urine, as unchanged or conjugates of Mefenamic acid and its metabolites.
