Potentially serious hypokalemia can occur in large doses. Hypersensitivity reactions including paradoxical bronchospasm, angioedema, urticaria, hypotension and collapse may also occur.
Adverse effects with guaifenesin are rare. Guaifenesin is safe and generally well tolerated. Nausea, vomiting and other mild gastrointestinal discomfort may occur in some individuals who are given very large doses.
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