Vert Mechanism of Action

Pharmacology: The mechanism of action of betahistine hydrochloride is not known. Pharmacological testing in animals has shown that the blood circulation in the striae vascularis of the inner ear improved, due to relaxation of the precapillary sphincter of the microcirculation of the inner ear. In the pharmacological studies, betahistine hydrochloride was found to have weak H1-receptor agonist and considerable H3-antagonist properties in the CNS and automatic nervous system. Betahistine hydrochloride was found to have a dose dependent inhibiting effect on spike generation of neurons in lateral and medial vestibular nuclei. The importance of this observation in the action against Meniere's syndrome of vestibular vertigo, however, remains unclear.
Betahistine hydrochloride is completely absorbed after oral administration.
Only one metabolite, 2-pyridylactic acid which is excreted in urine is known.