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Solution Preparation: Each vial of Zoledronic acid is reconstituted with 5 ml of sterile water for injection, aseptically. Agitate until total dissolution. To prepare a solution for infusion containing 8 mg Zoledronic acid, two 4 mg vials must be aseptically reconstitute by adding 5 ml of sterile water for injection to each of them, as described above. In both cases, the resulting solution must be diluted in 50 ml sodium chloride solution at 0.9% w/v or glucose solution at 5% w/v.
Patients must be maintained well hydrated prior to and following administration of Zoledronic acid.
Zoledronic acid concentrate must not be mixed with calcium or other divalent cation-containing infusion solutions such as lactated Ringer's solution, and should be administered as a single intravenous solution in a separate infusion line.
Patients must be maintained well hydrated prior to and following administration of Zoledronic acid.
solution should be used immediately. Otherwise, storage prior to use is responsibility of the healthcare professional, and should be stored at 2°C and 8°C, and let the solution return to room temperature before administration. The time from reconstitution, to dilution and administration, should not exceed 24 hours in total.
