Vigor-ACE Adverse Reactions

The amount of nutrients in this product is relatively nontoxic and is usually well tolerated. However, undesirable effects may occur, particularly when the nutrients are used at high doses (e.g., concomitant use of other multivitamin-mineral supplements), see also Overdosage.
Vitamin A: Dermatitis and photosensitivity reactions may occur.
Vitamin C: Vitamin C at a dose of 1 g or more daily may cause diarrhea. Other gastrointestinal (GI) disturbances associated with high vitamin C intake include nausea, vomiting, abdominal cramps, heartburn, esophagitis (rare), transient colic, and flatulent distension. Fatigue, flushing, headache, insomnia, sleepiness, and mild increase in urination have also been reported.
Ascorbic acid may cause acidification of the urine, precipitation of urate, cystine, or oxalate stones, or drugs in the urinary tract. However, reports of kidney stone formation associated with large dosages of ascorbic acid reportedly have been limited to individuals with preexisting renal disease, and data from epidemiologic studies do not support an association between excess ascorbic acid intake and kidney stone formation in apparently healthy individuals.
Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency reportedly have developed hemolysis after large oral doses of ascorbic acid. Rarely, decreased blood pH leading to sickle-cell crisis has been reported in patients with sickle-cell disease.
Vitamin E: Vitamin E (e.g., at dosages exceeding 300 IU daily) has rarely caused nausea, diarrhea, abdominal pain/intestinal cramps, fatigue/weakness, headache, dizziness, blurred vision, emotional disturbances, and rash. Myopathy (muscle disorder), hypertension, thrombophlebitis (vein inflammation related to a blood clot), gonadal dysfunction, breast soreness/gynecomastia, creatinuria (increased concentration of creatine in the urine), increased serum creatine kinase, serum cholesterol, and triglycerides; increased urinary estrogens and androgens; and thyroid problems have also been noted. These effects generally disappeared after discontinuing the vitamin.
Doses of vitamin E greater than 1,000 mg (equivalent to 1,490 IU) daily for prolonged periods have occasionally been associated with increased bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants. It has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens.
Selenium: Excessive selenium exposure may cause abdominal pain and cramps, diarrhea, nausea, vomiting, garlic-like breath odor, hair and nail changes, fatigue, and irritability.
Zinc: Doses of zinc up to 30 mg/day are generally well tolerated. Higher doses may cause gastrointestinal (GI) side effects such as nausea, vomiting, abdominal pain/cramps, dyspepsia, GI discomfort/irritation, gastritis, and diarrhea. Other adverse reactions reported include metallic taste, loss of appetite, headache, and drowsiness.