Vigor-ACE Drug Interactions

The following interactions have been noted particularly when the nutrients are used at high doses: Vitamin A: Anticoagulant (e.g., warfarin): Concomitant administration with large doses of vitamin A may lead to increased risk of bleeding.
Retinoid (e.g., etretinate, isotretinoin, tretinoin): Avoid concomitant use of retinoids and preparations containing vitamin A or its derivatives because of the potential for additive undesirable effects.
Minocycline: Concomitant administration may lead to increased risk of pseudomotor cerebri.
Statins: Prolonged statin treatment may increase serum vitamin A levels.
Vitamin C: Paracetamol: Ascorbic acid increases the apparent half-life of paracetamol.
Vitamin E: Anticoagulants: Vitamin E reportedly may have anti-vitamin K effects; concomitant intake of anticoagulants (e.g., warfarin) and vitamin E may result in hemorrhage (bleeding).
Antiplatelets: High doses of vitamin E may also potentiate the effects of antiplatelets (e.g., aspirin, clopidogrel, ticlopidine) and herbs with antithrombotic activity such as garlic and ginkgo.
Zinc: Antibiotics (cephalosporins, quinolones, tetracyclines): Zinc decreases the absorption of these antibiotics. Taking the antibiotic at least 2 hours before or 4 to 6 hours after taking zinc supplement minimizes this interaction.
Bisphosphonates (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration; use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Tell the doctor about other medicines the patient is taking including supplements and herbal products.