Zarzio Indications/Uses

Reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukemia and myelodysplastic syndromes) and reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at risk of prolonged severe neutropenia.
The safety and efficacy of filgrastim are similar in adults and children receiving cytotoxic chemotherapy.
Mobilisation of peripheral blood progenitor cells (PBPCs).
In patients, children or adults, with severe congenital, cyclic or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤0.5 x 10⁹/L, and a history of severe or recurrent infections, long term administration of filgrastim is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events.
Treatment of persistent neutropenia (ANC ≤1.0 x 10⁹/L) in patients with advanced HIV infection in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate.