Pyrazinamide is usually given daily or 3 times a week. Recommended oral doses for adults and children are up to 35 mg/kg body weight daily (maximum daily dose is 3 g) or 50 mg/kg 3 times a week, or 75 mg/kg twice weekly. In partial intermittent therapy, pyrazinamide is administered daily for the first 2 months with isoniazid and rifampicin. Afterwards, treatment with isoniazid and rifampicin will continue for the next 4 months.
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