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Liver functions should be assessed before and regularly during treatment.
Caution should be observed in patients with impaired renal functions or a history of gout. Pyrazinamide should be discontinued, in the event of severe arthralgia or attack of gout.
Pyrazinamide should be used with caution in patients with diabetes mellitus, as their management may become more difficult.
Use in pregnancy & lactation: Pyrazinamide should not be given during pregnancy unless the potential benefit outweighs the potential risk to the fetus.
Pyrazinamide passes into the breast milk; the adverse effect on the infant are unknown. Therefore, the benefits and risks of nursing infant should be carefully considered.
