Zyclor Special Precautions

Aciclovir should be used with caution in patients with underlying neurologic abnormalities and in patients with serious renal, or electrolyte abnormalities or substantial hypoxia. Caution must also be used in concurrent use of aciclovir with nephrotoxic drugs since the risk of aciclovir-induced renal impairment and/ or reversible CNS symptoms is increased. Systemic aciclovir should be used with caution and in reduced doses in patients with renal impairment. The elderly and patients with existing renal impairment should be closely monitored for neurological adverse effects. Adequate hydration should be maintained in patients given parenteral or high oral doses of aciclovir. Intravenous doses should be given by infusion over one hour to avoid precipitation of aciclovir in the kidney; rapid or bolus injection should be avoided. The risk of renal impairment is increased by use with other nephrotoxic drugs. Intravenous aciclovir should also be used with caution in patients with underlying neurological abnormalities, with significant hypoxia, or with serious hepatic or electrolyte abnormalities.
Intramuscular and subcutaneous injection must be avoided as well as rapid bolus intravenous injection.