Sign Out
Symptoms: Overdose symptoms essentially represent an increase of the pharmacological effects: somnolence, mental confusion, drowsiness and muscle relaxation or paradoxical excitement. The most serious symptoms would be areflexia, apnoea, hypotension, cardiorespiratory depression and coma.
Treatment: In most of the cases, simply monitor the patient's vital signs. For overdose treatment, special attention should be paid to cardiorespiratory function at the intensive care unit. Flumazenil, a benzodiazepine antagonist is indicated for serious overdose accompanied by coma or respiratory depression. Flumazenil is to be used with extreme caution in the presence of mixed overdose and in patients with epilepsy already treated with benzodiazepines. Flumazenil should not be used in patients receiving tricyclic antidepressants, or epileptogenic drugs, or in patients with ECG alterations (QRS or QT prolongation).
