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Therapeutic Classification: Antifungal Agent.
Pharmacology: Fluconazole is a highly selective inhibitor of fungal cytochrome P-450 sterol C-14-alphademethylation. Mammalian cell demethylation is much less sensitive to fluconazole inhibition. The subsequent loss of normal sterols correlates with the accumulation of 14-alpha-methyl sterols in fungi and may be responsible for the fungistatic activity of fluconazole.
