Apo-Zopiclone Adverse Reactions

The most common adverse reaction seen with zopiclone is taste alteration (bitter taste). Severe drowsiness and/or impaired coordination are signs of drug intolerance or excessive doses.
The following adverse events were observed in patients receiving zopiclone. In the absence of an established cause-effect relationship, those adverse reactions that were observed more frequently with zopiclone than with a placebo are with the symbol (^*).
Central Nervous System: Somnolence^*, asthenia^*, dizziness^*, confusion^*, anterograde amnesia^* or memory impairment^*, feeling of drunkenness^*, euphoria^*, nightmares, agitation, anxiety^* or nervousness^*, hostility, depression^*, decreased libido, coordination abnormality^*, hypotonia^*, tremor, muscle spasms, paresthesia, speech disorder^*.
Cardiovascular: palpitations.
Digestive: dry mouth, coated tongue, bad breath, nausea, vomiting, dyspepsia, diarrhea, constipation, anorexia or increased appetite.
Respiratory: dyspnea.
Special senses: amblyopia.
Dermatologic: rash, spots on skin, sweating. Rashes may be a sign of drug hypersensitivity; discontinue if this occurs.
Metabolic and Nutritional: weight loss.
Others: bitter taste, headache, limb heaviness, chills.
Laboratory Tests: There have been sporadic reports of abnormal laboratory test values including increase in ASAT, ALAT or alkaline phosphatase values.
Geriatric Patients: Geriatric patients tended to have a higher incidence of palpitations, vomiting, anorexia, diarrhea, confusion, agitation, anxiety, tremor and sweating than younger patients.