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Involuntary or accidental cases of zopiclone overdosage involving doses up to 340 mg, the principal effects reported were prolonged sleep, drowsiness, lethargy and ataxia.
Full manifestation of zopiclone overdosage can be expected to be consistent with its pharmacological activity, i.e., somnolence, confusion and coma with reduced or absent reflexes.
Treatment should be supportive and in response to clinical signs and symptoms. Respiration, pulse and blood pressure should be monitored and supported by generally measures when necessary. Immediate gastric lavage should be performed. Intravenous fluid should be administered and an adequate airway maintained. Hemodialysis is probably of no value. It should be borne in mind that multiple agents may have been ingested.
