Higher frequency of adverse events w/ ACE inhibitors, angiotensin II receptor blockers or aliskirin. May increase hypotensive effects w/ other antihypertensive agents. May increase serum K levels w/ K-sparing diuretics, supplements, salt substitutes containing K or other medicinal products that may increase serum K levels (eg, heparin). Monitor for possible increase in serum conc of lithium. Attenuation of antihypertensive effect & increased risk of renal impairment in concomitant w/ NSAIDs [ie, selective COX-2 inhibitors, acetylsalicylic acid (>3 g/day) & nonselective NSAIDs].