Immediately discontinue use if thrombophlebitis, cerebrovascular disorders, pulmonary embolism & retinal thrombosis occur. Consider non-function causes in cases of breakthrough bleeding. Carefully observe conditions that might be influenced by the potential fluid retention factor eg, epilepsy, migraine, asthma, cardiac or renal dysfunction; patients w/ history of psychic depression (discontinue if depression recurs to a serious degree); diabetic patients. Severe hepatic impairment.