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Pharmacology: Pharmacodynamics: Those of the naturally occurring progesterone with induction of a full secretory endometrium.
Pharmacokinetics: The progesterone vaginal gel is based on a Polycarbophil delivery system which attaches to the vaginal mucosa and provides a prolonged release of Progesterone for at least three days.
Toxicology: Preclinical safety data: In rabbits, Crinone was an eye irritant categorized as class IV (minimal effects clearing in less than 24 hours), but not a dermal irritant. A moderate vaginal irritation was found in rabbits after application of 2.0 ml/day of 8 % gel for 5 days.
