No synergy has been demonstrated in vitro in most studies between Fusidic Acid and Rifampicin or vancomycin, and antagonism of the effects of ciprofloxacin has been reported. Interactions with the penicillins are complex, with either antagonism of the effect of one or both agents, or lack of any effect. However, the combination of an antistaphylococcal penicillin with Fusidic Acid may prevent the emergence of Fusidic Acid-resistant staphylococcal mutants, and such combinations may be clinically effective.
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