Fobancort Mechanism of Action

Pharmacology: Pharmacodynamics: Fusidic Acid and its salts exert antibacterial activity against most Gram positive organisms; in particular, they are effective against pathogenic Staphylococci, including the penicillinase-producing strains. They have slight or no activity against Gram negative organisms and fungi. Betamethasone Dipropionate is a topically active fluorinated corticosteroid which has anti-inflammatory anti-pruritic and vasoconstrictive actions.
Pharmacokinetics: Fusidic Acid and its salts are widely distributed into tissues and body fluids, including bone, pus, and synovial fluid; they penetrate cerebral abscesses but do not enter cerebrospinal fluid in appreciable amounts. They have been found in foetal circulation and in breast milk. About 95% or more of Fusidic Acid or Sodium Fusidate in the circulation is bound to plasma protein. Fusidic Acid or Sodium Fusidate is excreted in the bile, almost entirely as metabolites some of which have weak antimicrobial activity. About 2% appears unchanged in the faeces. Little is excreted in the urine or removed by haemodialysis.
Betamethasone Dipropionate has anti-inflammatory, anti-pruritic and vasoconstrictive actions. When administered topically, particularly under occlusive dressing or when the skin is broken, sufficient corticosteroid may be absorbed to give systemic effects. Corticosteroids are extensively bound to plasma proteins. Only unbound corticosteroids have pharmacological effects or are metabolised. They are metabolised mainly in the liver, also in the kidneys, and are excreted in the urine.