Adacel Drug Interactions

Vaccine-Drug Interactions: Immunosuppressive treatments may interfere with the development of the expected immune response. (See PRECAUTIONS.)
Concomitant Vaccine Administration: ADACEL may be administered concurrently with a dose of trivalent inactivated influenza vaccine and with a dose of hepatitis B vaccine in 11 to 12 year-olds.
The concomitant use of ADACEL and trivalent inactivated influenza vaccine was evaluated in a clinical trial involving 696 adults 19 to 64 years of age. The safety and immunogenicity profiles in adults that received the vaccines concomitantly were comparable to those observed when the vaccines were given on separate occasions one month apart.
The concomitant use of ADACEL and hepatitis B vaccine was evaluated in a clinical trial involving 269 adolescents 11 to 12 years of age. The safety and immunogenicity profiles in adolescents that received the vaccines concomitantly were comparable to those observed when the vaccines were given on separate occasions one month apart. No interference was observed in the immune responses to any of the vaccine antigens when ADACEL and hepatitis B vaccines were given concurrently or separately.
Vaccines administered simultaneously should be given using separate syringes at separate injection sites and preferably in separate limbs. ADACEL should not be mixed in the same syringe with other parenterals.