IV Administer at max rate of 10 mL/min.
Early haemarthrosis, muscle or oral bleeding 20-40 IU/dL. Repeat inj every 12-24 hr at least 1 day until bleeding episode is resolved or healing is achieved.
More extensive haemarthrosis, muscle bleeding or haematoma 30-60 IU/dL. Repeat inj every 12-24 hr for 3-4 days or more until pain & acute disability are resolved.
Life threatening haemorrhages 60-100 IU/dL. Repeat inj every 8-24 hr until threat is resolved.
Minor surgery including tooth extraction 30-60 IU/dL every 24 hr at least 1 day until healing is achieved.
Major surgery (pre- & post-op) 80-100 IU/dL. Repeat inj every 8-24 hr until adequate wound healing, then continue treatment for at least another 7 days to maintain factor VIII activity of 30-60% (IU/dL).
Long-term prophylaxis 40-50 IU/kg twice wkly in 3-4 day intervals.
Childn <12 yr Initially 40-60 IU/kg twice wkly. Adjust dose based on clinical response up to max of 70 IU/kg.
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