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Pharmacology: Pharmacokinetics: Tab: Absorption: Poor; may increase up to 5 times when administered with a fatty meal.
Distribution: Well inside hydatid cysts and CSF.
Protein binding: 70%
Metabolism: Hepatic; extensive first-pass effect; pathways include rapid sulfoxidation to active metabolite [albendazole sulfoxide (major)], hydrolysis, & oxidation.
Half-life elimination: 8-12 hours.
Time to peak, serum: 2-5 hours
Excretion: Urine (<1% as active metabolite); feces.
