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PHARMACOKINETICS: Absorption: Oral absorption is poor (<5%); may increase up to 4-5 times when administered with a fatty meal.
Distribution: Well distributed inside hydatid cysts; excellent CSF (Cerebrospinal Fluid) concentrations.
Protein binding: 70%.
Metabolism: Extensive first-pass metabolism; metabolic pathways include rapid sulfoxidation (major), hydrolysis, and oxidation.
Half-life: 8 - 12 hours.
Time to peak serum concentration: 2 - 2.4 hours.
Elimination: Active and inactive metabolites excreted in urine.
