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Overdosage of Aldara in humans is unlikely due to minimal percutaneous absorption. Animal studies reveal a dermal lethal dose of >5000 mg/kg. Persistent topical overdosing of Aldara could result in severe local skin reactions. These usually subside within 2 weeks of discontinuation.
Following accidental ingestion of a single 200 mg imiquimod (corresponds to the content of approximately 16 sachets), nausea, emesis, headache, and fever can occur. The most clinically serious adverse event reported following multiple oral imiquimod doses of >200 mg was hypotension, which resolved following oral or IV fluid administration.
