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Amlodipine causes no change in digoxin's pharmacokinetics in healthy volunteers.
Cimetidine does not alter the kinetic profile of amlodipine.
No drug interaction occurs between amlodipine and nitroglycerin.
Azole antifungals (e.g. itraconazole, ketoconazole, fluconazole), erythromycin and CYP3A4 inhibitors inhibit metabolism of amlodipine.
Coadministration of grapefruit juice with amlodipine may increase serum levels of amlodipine.
Amlodipine should be used with caution when coadministered with sildenafil, tadalafil or vardenafil since blood pressure lowering effects of these drugs are additive with amlodipine.
