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Preparations containing ethinyl estradiol, cyproterone combinations should not be used in the presence of any of the conditions listed as follows: 1. Hypersensitivity to ethinyl estradiol, cyproterone, or any component of the formulation.
2. Current or history of breast cancer or other estrogen-dependent or progestin-dependent neoplasm.
3. Hepatic tumors or liver disease.
4. History of cholestatic jaundice.
5. Pregnancy.
6. Undiagnosed abnormal vaginal bleeding.
7. Ocular lesions arising from ophthalmic vascular disease.
8. History of otosclerosis with deterioration during pregnancy.
9. Women at high risk of arterial or venous thrombotic disease including cerebrovascular disease, coronary artery disease, MI, diabetes mellitus with vascular disease.
