Avoid concomitant use of cyproterone acetate and ethinyl estradiol with any of the following: anastrozole, conivaptan, pimozide, pirfenidone.
Cyproterone acetate and ethinyl estradiol may increase the effects of aripiprazole, benzodiazepines, corticosteroid, CYP1A2 substrates, HMG-CoA reductase inhibitors, lomitapide, pimozide, pirfenidone, ropinirole, selegiline, theophylline derivatives, tipranavir, tizanidine, tranexamic acid, voriconazole.
The level of cyproterone acetate and ethinyl estradiol may be increased by: ascorbic acid, conivaptan, CYP3A4 inhibitors (strong, moderate), ivacaftor, mifepristone, NSAID (COX-2 inhibitor), voriconazole.
Cyproterone acetate and ethinyl estradiol may decrease the effects of anastrozole, chenodiol, CYP1A2 substrates, CYP2E1 substrates, hyaluronidase, lamotrigine, thyroid products, ursodiol, vitamin K antagonists.
The level of cyproterone acetate and ethinyl estradiol may be decreased by aminoglutethimide, aprepitant, armodafinil, artemether, barbiturates, bexarotene, bile acid sequestrants, boceprevir, bosentan, carbamazepine, clobazam, cobicistat, colesevelam, CYP3A4 inducers (strong), deferasirox, elvitegravir, exenatide, felbamate, fosaprepitant, fosphenytoin, griseofulvin, mifepristone, modafinil, mycophenolate, nafcillin, nevirapine, oxcarbazepine, phenytoin, protease inhibitors, prucalopride, retinoic acid derivatives, rifamycin derivatives, rufinamide, St. John's Wort, telaprevir, tipranavir, tocilizumab, topiramate.