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The occurrence of a neurologic or severe hypersensitivity reaction following a previous dose is a contraindication to further use of this product. The administration of booster doses more frequently than recommended may be associated with increased incidence and severity of reactions. Persons who experience Arthus-type hypersensitivity reactions or temperature greater than 39°C after a previous dose of tetanus toxoid usually have very high serum tetanus antitoxin levels and should not be given even emergency doses of tetanus toxoid more frequently than every 10 years, even if they have a wound that is neither clean nor minor.
Adsorbed Tetanus Vaccine should not be given to individuals with thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injection, unless the potential benefit clearly outweighs the risk of administration.
Patients with impaired immune responsiveness may have a reduced antibody response to active immunization procedures.
Special care should be taken to prevent injection into blood vessel
